2 ERC-funded postdoctoral positions focusing on therapeutic brain delivery > VIB > Joboolo BE :
Société : VIB Lieu : Ghent Flanders Site source : Talent BE
Our pioneering research harnesses the power of single-domain antibodies, also known as nanobodies or VHHs, as a Trojan horse for targeted braindelivery.
Our goal is to explore the vast potential of VHHs in effectively transporting diverse cargos -ranging from proteins to nucleic acids and nanoparticles - across the blood-CSF barrier, offering promising solutions for a myriad of neurological disorders.
We previously identified a promising candidate that requires further optimization and validation and in addition, we aim to discover novel VHHs capable of crossing the blood-CSF barrier and delivering therapeutic cargoes to the brain.ProfileYou will become an integral part of a subteam, collaborating with an experienced lab technician and a dedicated PhD student whose project focuses on in vitro screening methods, using a.o.
organoids.
We are looking for individuals with expertise in the following specific profiles to enhance and complement the team:
Profile 1Ph.D.
in Pharmaceutical sciences or related fields.Demonstrated expertise in:
Drug delivery.
Profile 2Ph.D.
in Molecular biology or related fields.Demonstrated expertise in:
In vitro and/or in vivo phage display; Cloning, engineering, expression, purification and characterization of VHHs.
We invite applications from dynamic individuals with a strong drive for innovation and motivation.
Ideal candidates will possess critical thinking abilities, excellent oral and written communication skills in English, and a collaborative mindset.
Additionally, they should demonstrate the capacity to independently plan and execute research with precision.
A keen interest in drug delivery, nanobodies, neuroinflammation, and/or brain barriers is essential, accompanied by hands-on experience in molecular biology and/or biochemistry techniques.
Proficiency in advanced microscopy, in vitro cell culture and organoid-based brain barrier models and/or experience with in vivo mouse experiments (Felasa C) will be considered advantageous.
If you are passionate about pioneering research at the intersection of neuroinflammation and therapeutic innovation, we encourage you to submit your application.Join us to undertake a highly innovative project that combines cutting-edge approaches including state-of-the-art imaging techniques, pluripotent stem cell models, in vivo mouse models of neurological disorders, drug (brain) delivery and nanobody development.We offerA state-of-the-art laboratory environment.A versatile and challenging academic position with very diverse contacts in a world-class research environment operating at an international level, and various opportunities to broaden your expertise.Opportunities to train in many cutting-edge technologies.Training courses in academic, technical, and career skills.A competitive salary and a range of benefits including a bicycle allowance and eco vouchers.An initial 1-year contract, which can be extended up to 5 years.Starting Date:
